A Monoclonal Antibody Recognizing an Iscosapeptide Sequence in the Heavy Chain of Human Factor XII Inhibits Surface-Catalyzed Activation

作者: Robin A. Pixley , Robert W. Colman

DOI: 10.1007/978-1-4615-9543-4_72

关键词:

摘要: A monoclonal antibody (mAb B7C9) to human factor XII was produced which blocked the surface mediated coagulant activity of but not amidolysis H-D-ProPheArg-pNA. The mAb epitope localized a 20 amino acid sequence 2.5 kDa in heavy chain XII.

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