Circulating catecholamines and sympathetic activity after head injury.

摘要: Plasma norepinephrine (NE) and dopamine beta-hydroxylase (DBH) levels were measured during the first 7 days after head injury in 48 patients. Blood pressure, pulse, temperature, Glasgow coma score (GCS) recorded at time of sampling for each patient, relationships these to NE DBH examined. In patients with multiple trauma, usually elevated, regardless GCS. alone, however, was proportional Alert a brief loss consciousness (GCS, 14) had normal levels. Those as high times normal. temperature found be elevated proportionally elevations plasma injury. The finding severe raises possibility adverse effects sympathetic hyperactivity injury, including hypermetabolism, cardiovascular abnormalities, direct catecholamines on damaged central nervous system.