Lysophosphatidic acid-induced mitogenesis is regulated by lipid phosphate phosphatases and is Edg-receptor independent.
作者： Shelley B. Hooks , Webster L. Santos , Dong-Soon Im , Christopher E. Heise , Timothy L. Macdonald
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摘要: Lysophosphatidic acid (LPA) is an extracellular signaling mediator with a broad range of cellular responses. Three G-protein-coupled receptors (Edg-2, -4, and -7) have been identified as for LPA. In this study, the ectophosphatase lipid phosphate phosphatase 1 (LPP1) has shown to down-regulate LPA-mediated mitogenesis. Furthermore, using degradation-resistant phosphonate analogs LPA stereoselective agonists Edg we demonstrated that mitogenic platelet aggregation responses are independent Edg-2, -7. Specifically, found degradation insufficient account decrease in potency assays, stereoselectivity observed at not reflected Additionally, RH7777 cells, which devoid -7 receptor mRNA, response analogs. Finally, determined ligand selectivity consistent mitogenesis, but
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