Interferon-γ and NF-κB mediate nitric oxide production by mesenchymal stromal cells
作者： I. Oh , K. Ozaki , K. Sato , A. Meguro , R. Tatara
DOI: 10.1016/J.BBRC.2007.02.054
关键词:
摘要: Mesenchymal stromal cells (MSCs) have been shown to an immunosuppressive effect. Previously, we demonstrated that nitric oxide (NO) is one of the immunomodulatory mediators MSCs. We herein show primary mouse bone marrow MSCs and three cell lines mimic suppress both differentiation proliferation in Th1 condition, whereas suppression Th2 condition mild. NO production inversely correlated with T conditions. highly induced minimally Th2. Moreover, inhibitor synthase restores interferon-{gamma} (IFN-{gamma}) condition. Furthermore, anti-IFN-{gamma} antibody strongly inhibits NF-{kappa}B reduces level induction inducible (iNOS) Taken together, our results suggest plays a significant role modification by MSCs, IFN-{gamma} are critical for
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