Vascular Endothelial Growth Factor-A (VEGF-A) Mediates Activin A-Induced Human Trophoblast Endothelial-Like Tube Formation

摘要: Remodeling of maternal spiral arteries during pregnancy requires a subpopulation extravillous cytotrophoblasts (EVTs) to differentiate into endovascular EVTs. Activin A, which is abundantly expressed at the maternal-fetal interface, has been shown promote trophoblast invasion, but its role in differentiation remains unknown. Vascular endothelial growth factor-A (VEGF-A) well recognized as key regulator differentiation. Whether and how activin A might regulate VEGF-A production human trophoblasts relationship have yet be determined. In present study, we found that increased primary immortalized (HTR8/SVneo) EVT cells. addition, enhanced HTR8/SVneo endothelial-like tube formation, these effects were attenuated by pretreatment with small interfering RNA targeting or VEGF receptor 1/2 inhibitor SU4312. Pretreatment activin/TGF-β typ...