OCTANE (Ontario-wide Cancer Targeted Nucleic Acid Evaluation): a platform for intraprovincial, national, and international clinical data-sharing
作者： E. R. Malone , R. R. Saleh , C. Yu , L. Ahmed , T. Pugh
DOI: 10.3747/CO.26.5235
关键词:
摘要: Cancer is a genetic disease resulting from germline or somatic aberrations. Rapid progress in the field of genomics recent years allowing for increased characterization and understanding various forms disease. The Ontario-wide Targeted Nucleic Acid Evaluation (octane) clinical trial, open at cancer centres across Ontario, aims to increase access genomic sequencing tumours facilitate collection data related enrolled patients their outcomes. study designed assess utility next-generation (ngs) patient care, including enhancement treatment options available patients. A core aim encourage collaboration between hospitals within Ontario while also increasing international terms sharing newly generated data. single-payer provincial health care system provides unique opportunity develop province-wide registry ngs testing repository genomically characterized, clinically annotated samples. It an important use real-world evaluate outcomes cost with advanced cancer. octane attempting translate knowledge help deliver precision oncology Canadian environment. In this article, we discuss background its implementation, current status, future directions.
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