Prophylactic oophorectomy: a morphologic and immunohistochemical study.

摘要: BACKGROUND. The tumorigenesis of ovarian carcinoma is poorly understood. authors studied morphologic features and immunohistochemical expression patterns neoplasia-associated markers in prophylactically removed ovaries, normal papillary serous carcinomas to identify possible preneoplastic changes surface epithelium. METHODS. Morphologic CA-125, Ki-67, p53, E-cadherin, Bcl-2 were evaluated 21 31 ovaries that for increased risk, 7 carcinomas. Representative slides from formalin-fixed, paraffin-embedded tissue blocks submitted staining independently by three gynecologic pathologists. For statistical analyses, Fisher exact tests, multivariate Spearman rank correlation coefficients, Wald statistics, Kruskal-Wallis Mann-Whitney tests used. Immunohistochemical results correlated with findings. RESULTS. found progressive increases reactivity the lowest epithelium, stronger epithelium highest Ki-67 p53. A similar trend was observed CA-125. Positivity p53 seen predominantly inclusion cysts deep invaginations, including those areas had been identified as hyperplastic or dysplastic on routine hematoxylin eosin-stained sections. CONCLUSIONS. current suggest biologic/molecular evidence existence support previously proposed concept dysplasia. Subtle alterations may be biologically significant.