Insulin resistance for glucose metabolism in disused soleus muscle of mice

摘要: Our hypothesis was that insulin resistance for carbohydrate metabolism develops after a single day of muscular disuse. The immobilization the mouse hindlimb 24 h used to produce disuse (group c). As food intake voluntarily decreased during immobilization, two additional groups were used: group A untreated and ate ad libitum, whereas B anesthetized with C fed amounts similar those eaten by C. Because differed only limb as reference group. When present in incubation media, rates 2-deoxyglucose uptake glycogen synthesis always significantly soleus muscles from (anesthetized, less, immobilized) compared pair-fed ate). Significant interaction between factors support concept skeletal muscle attenuates action. These observations are direct demonstration decrease responsiveness result inactivity. plasma concentrations lower than group, it seems likely development disused is independent levels.