Induction of Kidney Epithelial Morphogenesis by Cells Expressing Wnt-1

摘要: During kidney development, unknown signals derived from the ureteric bud induce metanephric mesenchymal cells to differentiate into nephron epithelia. In addition bud, a number of other tissues can act as heterologous inducers this process in vitro, including embryonic spinal cord. report we demonstrate that Wnt-1, gene encodes secreted glycoprotein expressed cord, is capable conferring nephron-inducing activity fibroblast cell lines. When cocultured with expressing exogenous mesenchyme differentiated glomerular and renal tubular No such effect was observed using control cells. These data imply ability cord an inducer nephrogenesis may result its production Wnt-1 protein suggest member Wnt family be mediator epithelial morphogenesis vivo.