Pediatric familial type II hyperlipoproteinemia: therapy with diet and cholestyramine resin.

摘要: Effects of a low-cholesterol, polyunsaturate-rich diet and synthetic organic bile sequestrant polymer (U26,597A, colestipol) were studied in 21 children, heterozygous for familial hypercholesterolemia. Total cholesterol, beta-lipoprotein triglyceride measured twice on habitual diet, monthly six months low-cholesterol plus 10 gm colestipol per day. cholesterol (mean +/- 1 SD) was 295 37 278 29 fell significantly to 242 mg/100 ml colestipol. Low-density lipoprotein (LDL) 234 220 28 179 26 drug. Plasma levels 79 31, remained unchanged 86 22, unaffected by drug, 85 17 ml. On alone, plasma LDL not normalized (less than 170 ml) any the within normal limits 230 only one child. The combination resin total 52% children. Cholesterol lowered "moderately elevated" range 250 an additional 14% children 190 29%. In 33% greater despite colestipol, while 19%. Colestipol is effective well-tolerated lowering compound which, conjunction with may prove be very useful treatment