The mouse Y* chromosome involves a complex rearrangement, including interstitial positioning of the pseudoautosomal region.

摘要: Cytological analysis of the mouse Y* chromosome revealed a complex rearrangement involving acquisition functional centromere and centromeric heterochromatin attachment this chromosomal segment to distal end normal chromosome. This positioned short-arm region at pseudoautosomal interstitially, just newly acquired centromere. In addition, majority was inverted. Recombination between X chromosomes generates two new sex chromosomes: (1) large comprised attached its all but missing (XY*) (2) small containing portion G-band-negative material from (YX). Mice that inherit XY* develop as sterile males, whereas mice Y*X fertile females. Recovery equal numbers recombinant nonrecombinant offspring males supports hypothesis recombination mammalian Y is necessary for primary spermatocytes successfully complete spermatogenesis form sperm.