Patterns of Regional Cerebral Blood Flow as a Function of Age Throughout the Lifespan
作者： Daniel G. Amen , Sachit Egan , Somayeh Meysami , Cyrus A. Raji , Noble George
DOI: 10.3233/JAD-180598
关键词:
摘要: Background Understanding the influence of aging on brain remains a challenge in determining its role as risk factor for Alzheimer's disease. Objective To identify patterns large neuroimaging cohort. Methods A psychiatric cohort 31,227 individuals received SPECT at rest and during concentration task total 62,454 scans. ANOVA was done to mean age trends over course range this group, 0-105 years. regression model which regions interest used predict chronological (CA) then utilized derive estimated (BEA). The difference between CA BEA calculated determine increased common disorders our sample such depression, dementia, substance use, anxiety. Results Throughout lifespan, variations perfusion were observed childhood, adolescence, late life. Increased seen alcohol cannabis anxiety, bipolar, schizophrenia, attention-deficit/hyperactivity disorder, men. Conclusion Brain can feature varies function disorders.
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