MicroRNAs in neurodegenerative diseases and their therapeutic potential

摘要: MicroRNAs (miRNAs) are abundant, endogenous, short, noncoding RNAs that act as important post-transcriptional regulators of gene expression by base-pairing with their target mRNA. During the last decade, substantial knowledge has accumulated regarding biogenesis miRNAs, molecular mechanisms and functional roles in a variety cellular contexts. Altered certain miRNA molecules brains patients neurodegenerative diseases such Alzheimer Parkinson suggests miRNAs could have crucial regulatory role these disorders. Polymorphisms sites may also constitute an determinant disease risk. Additionally, emerging evidence points to specific targeting regulating particular proteins key pathogenesis. Considering amount susceptible neuronal populations appears be critical neurodegeneration, miRNA-mediated regulation represents new significant therapeutic prospects. In this review, implications several disorders potential interventions discussed.