Review article: the role of anticonvulsant drugs in postoperative pain management: a bench-to-bedside perspective.

摘要: Anticonvulsant drugs are effective in the treatment of chronic neuropathic pain but were not, until recently, thought to be useful more acute conditions such as postoperative pain. However, similar nerve injury, surgical tissue injury is known produce neuroplastic changes leading spinal sensitization and expression stimulus-evoked hyperalgesia allodynia. Pharmacological effects anticonvulsant which may important modulation these neural include suppression sodium channel, calcium channel glutamate receptor activity at peripheral, supraspinal sites. The purpose this article review preclinical evidence clinical trial data describing efficacy safety setting management. A Medline search was performed retrieve available literature on basic pharmacology they pertain Numerous laboratory studies have described analgesic different experimental models. Furthermore, several recent trials shown that anticonvulsants reduce spontaneous movement-evoked pain, well decrease opioid requirements postoperatively. Some early findings suggest further alleviate anxiety, accelerate functional recovery postsurgical Given incomplete currently non-opioid analgesics, identified benefits sparing, medications adjuncts for analgesia. Further research field warranted.