Natural Sulfur Products as Redox Modulators and Selective Inducers of Cell Death

摘要: Numerous plants, fungi and microorganisms contain organic sulfur compounds (OSCs), which during the last couple of decades have been associated increasingly with chemoprevention, antibacterial anticancer activity. These also play a particular role as intracellular redox modulators inducers apoptosis. Among various OSCs, redox-active, reactive species, such allicin polysulfanes (RSxR, R ≠ H, x ≥ 3) from garlic onion, show particularly interesting properties. are able to S-thiolate or oxidize wide range peptides proteins, hence modulate processes, either directly by oxidizing GSH GSSG, shifts balance more potentials. Such interference ‘thiolstat’ has widespread consequences, ranging an activation antioxidant defenses induction While S-thiolation may be most prominent mode action chemistry these many facets, including superoxide radical generation, binding metal centres metallo-proteins hydrophobic interactions cellular membranes proteins. Ultimately, reactions potential trigger apoptotic pathways.