Laryngeal mucosal malignant melanoma. A clinicopathologic, immunohistochemical, and ultrastructural study of four patients and a review of the literature

摘要: Background. Primary laryngeal mucosal malignant melanomas are uncommon tumors that morphologically readily confused with more common types of cancer. Methods. Four cases primary melanoma were identified from the files Otolaryngic Tumor Registry-Armed Forces Institute Pathology. Clinical records available for all four cases. Paraffin blocks or unstained slides three The light microscopic features evaluated in Immunohistochemistry was performed cases; electron analysis two Follow-up data cases. Results. patients males and ranged age 35 to 84 years. clinical presentations included hoarseness, hemoptysis, dysphagia, airway obstruction, complaints ranging 1 8 months. sites involvement supraglottic larynx right true vocal cord. A history cutaneous a another site not reported any patients. Histologically, invasive composed pleomorphic epithelioid cell population cells. Malignant spindle-shaped could also be identified. presence melanin identifiable by microscopy Fontana stains confirmed other two. immunohistochemical findings showed diffuse immunoreactivity S-100 protein HMB-45. There no cytokeratin. specimen one patient demonstrated focal chromogranin. Electron premalonosomes melanosomes. Total laryngectomy treatment choice supplemented radiotherapy. information died meta-static disease within 36 months diagnosis. Metastasis occurred brain, lungs, spine, regional lymph nodes. fourth lost follow-up. Conclusions. Laryngeal is an neoplasm clinically pathologically simulates conventional cancers. microscopic, immunohistochemical, confirm Aggressive management indicated, as these disseminate widely rapidly fatal. Cancer 1995;75:1568-77.