Experimental rabies infection and oral vaccination in vampire bats (Desmodus rotundus).

摘要: Abstract A rabies virus variant isolated from a vampire bat (Desmodus rotundus) and characterized by genome sequencing was used for the standardization of an experimental infection in this species. The parenteral administration 106 MICLD50 capable inducing death 89% animals. mean duration post-challenge survival 12 days. None rabid bats showed aggressive behaviour.A vaccinia-rabies glycoprotein recombinant vaccine administered orally to on days −120, −90, −30 or −18 pre-challenge, same day challenge, +5 post-challenge. significant protection noticed only animals vaccinated pre-challenge. longer period incubation observed 5