摘要: Myeloproliferative neoplasms (MPNs) are stem cell-derived clonal myeloid malignancies characterized by a unique somatic mutational profile since three mutually exclusive mutations (JAK2V617F, MPL, and CALR) sustain the great majority of cases. However, clinical observation that autoimmune diseases may predispose to MPNs, disorders or phenomena be associated with genetic constitutional variants inflammatory also MPNs raises hypothesis there might an autoimmune/inflammatory basis underlying pathogenesis MPNs. Recent studies have documented abnormal activity key cells immune system, for example, increase in monocyte/macrophage compartment, altered regulatory T cell frequency, expansion myeloid-derived suppressor cells, CD4/natural killer dysfunction. This review is focused on summarizing recent advances our understanding immunological defects accompanying translational implications.
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