Oxidative stress leads to reduction of plasmalogen serving as a novel biomarker for systemic lupus erythematosus.

摘要: Oxidative stress is elevated in systemic lupus erythematosus (SLE) patients, and associated extensively with SLE pathogenesis. However, no common indicators of oxidative are yet routine clinical use because their instability, nonspecificity, non-representation all symptoms. Moreover, the method for reproducible analysis reactive oxygen species still lacking. Lipids metabolites essential components biological systems, many which serve as molecular targets play crucial roles signaling, inflammation, immune responses. Thus, determining changed levels lipids may needs research. In pilot study, shotgun lipidomics sera from 30 patients controls was performed revealed a marked reduction ethanolamine plasmalogen (pPE) 85.03±3.06 to 62.39±4.34 nmol/mL serum respectively, accompanying significant increases lysoPE (LPE) content (~46mol%) 4-hydroxynonenal (an indictor stress) patients. Representative proinflammatory cytokines were also determined, revealing elevation IL-6, IL-10, TNF-α Multivariate multiple regression analyses showed first time that correlation among disease activity index, IL-10 levels, pPE exists, providing insights into The study indicates changes (molecular peroxidation products novel biomarkers diagnosis SLE.