The Effect of Structure and Mechanism of the Hsp70 Chaperone on the Ability to Identify Chemical Modulators and Therapeutics

摘要: The role of the Hsp70 molecular chaperone in effecting proper cellular protein folding, transport, and degradation processes, stabilizing complexes, maintaining membrane integrity has long been recognized. More recently, linked to severe neurological diseases, such as Alzheimer’s, Parkinson’s Huntington’s disease, well cystic fibrosis cancer. As a result, there is growing interest development small-molecule modulators function. While several distinct classes agonists antagonists have identified date, clinical studies with Hsp70-targeted drugs yet be initiated, proof principle for therapeutic benefits remains established. However, large body preclinical biological evidence suggests that this plays key many human diseases associated (un)folding trafficking continued will yield novel strategies.