Interspecies scaling of biliary excreted drugs

摘要: Abstract The objective of this study is to predict clearance drugs in humans from animals which are excreted the bile. Clearance ( CL ) eight known be bile were randomly selected literature. Scaling was performed using at least three animal species. Using simple allometry,  × mean life‐span potential (MLP) or  × brain weight, s studied predicted humans. choice one methods depended on ‘rule exponents' as described by Mahmood and Balian. A ‘correction factor' calculated adjusting flow rate based species body weight (bile flow = mL/day/kg weight) liver weight). combining it with factor', biliary Predicted allometry several times higher for all (% error [range] = 46–1703). a report provided substantial improvement [range] = 5–91) prediction drugs. results indicate that drug may overpredicted applying employed here, predictability data significantly improved. © 2002 Wiley‐Liss, Inc. American Pharmaceutical Association J Pharm Sci 91:1908–1914,