Reduction of exercise‐induced asthma oxidative stress by lycopene, a natural antioxidant

摘要: Background: Lycopene has previously been shown to have high antioxidative activity. In view of the controversy regarding beneficial effect antioxidants on asthma, acute effects lycopene (LYC-O-MATOTM) airway hyperreactivity were assessed in patients with exercise-induced asthma (EIA). Methods: Twenty EIA participated our study verify effects. The test was based following sequence: measurement baseline pulmonary function, 7-min exercise session a motorized treadmill, 8-min rest and again 1-week, oral, randomly administered, double-blind supplementation placebo or 30 mg/day (LYC-O-MATO), function at rest, session, function. A 4-week washout interval allowed between each protocol. Results: All given showed significant postexercise reduction more than 15% their forced expiratory volume 1 s (FEV1). After receiving daily dose 30 mg for 1 week, 11 (55%) significantly protected against EIA. Serum analyses by high-pressure liquid chromatography detected lycopene-supplemented an elevated level compared group, no change retinol, tocopherols, other carotenoids. Conclusions: Our results indicate that exerts protective some patients, most probably through vivo effect.