Treatment for Diabetes

摘要: Methods and compositions for treating diabetes mellitus in a patient need thereof are provided. The methods include administering to composition providing gastrin/CCK receptor ligand, e.g., gastrin, and/or an epidermal growth factor (EGF) TGF-α, amount sufficient effect differentiation of pancreatic islet precursor cells mature insulin-secreting cells. can be administered systemically or expressed situ by transgenically supplemented with one both ligand gene, preprogastrin peptide gene EGF TGF-α gene. also transplanting into cultured islets which beta proliferated exposure ligand.