Renal Function-Based Contrast Dosing to Define Safe Limits of Radiographic Contrast Media in Patients Undergoing Percutaneous Coronary Interventions

摘要: Objectives The aim of this study was to evaluate the association between calculated creatinine clearance (CCC)-based contrast dose and renal complications in patients undergoing percutaneous coronary interventions (PCI). Background Excess volumes media are associated with cardiac procedures. Because excreted by kidney, we hypothesized that a estimation on basis CCC would provide simple strategy define safe media. Methods We assessed CCC-based risk contrast-induced nephropathy (CIN) need for in-hospital dialysis 58,957 PCI enrolled BMC2 (Blue Cross Blue Shield Michigan Cardiovascular Consortium) registry from 2007 2008. Patients receiving at time procedure were excluded. Results CIN requiring (NRD) directly increasing volume adjusted function. NRD approached significance when ratio dose/CCC exceeded 2 (adjusted odds [OR] CIN: 1.16, 95% confidence interval [CI]: 0.98 1.37, OR NRD: 1.72, CI: 0.9 3.27) dramatically elevated exceeding 3 1.46, 1.27 1.66, 1.89, 1.21 2.94). Conclusions Our supports minimizing dysfunction. A estimated function planned restricted less than thrice preferably twice might be valuable reducing NRD.