Methylation of Ethanolamine Phosphatides by Microsomes from Normal and Mutant Strains of Neurospora crassa

摘要: Abstract The phospholipid N-methyltransferase system in microsomes of normal Neurospora crassa was compared with those two choline-deficient mutant strains. transferase catalyzed the three transmethylations leading to synthesis lecithin, and phosphatide bases involved this sequence reactions were isolated as isotope-labeled products. a mutant, strain 34486, proved have subnormal phosphatidylethanolamine activity. second 47904, could not catalyze twostep conversion phosphatidylmonomethylethanolamine lecithin at measurable rate therefore deficient found strain. Evidence presented corroborate view based on previous studies that single enzyme N. converts lecithin.