Role of peptide growth factors in development of macrovascular complications of diabetes.

摘要: Peptide growth factors provide an important means of coordinating the cells within tissues and organs. Although their role in controlling cell is not well understood, they have been implicated derangements cellular proliferation that occur diabetes, e.g., mesangial hyperplasia atherosclerosis. Because several structurally characterized types on which act identified, research focusing developing model systems to determine whether are involved pathogenesis specific disease states. New techniques, i.e., situ hybridization, gene transfection, detailed structural analysis proteins, made it possible define both changes relative abundance potential actions These techniques being applied diabetes will make alterations occurred factor synthesis factor-matrix protein interaction cell-type-specific after loss normal glucose homeostasis. The findings from these analyses should lead a better understanding how complications develop rational strategies control effects.