THE ROLE OF HONEY WITH ROYAL JELLY IN PROTECTING THE GRAAFIAN FOLLICLES FROM THE TOXICITY OF THE ADRIAMYCIN DRUG

摘要: Objective: This study aims to investigate the ability of certain mixture honey with royal jelly (H+R) prevent toxic side effects, caused by Adriamycin drug. One most important effects this drug is change in structure cell and tissue ovary, especially Graafian follicles, which may lead sexual ovarian hormonal disorders. Consequently, will menstrual disorders that cases early menopause (infertility), decrease reproductive capacity. Methods: Twenty-five young adult female Syrian hamsters were injected (60-75 mg/m 2 (Aderiamycin another twenty-five females after oral administration preventive dose (800 mg/kg/day Honey 10 jelly). Histologically ovaries was conducted hymatoxylin & eosin staining, an immunohistochemical applied using immune. (Ki67) specialized for disclosure divisions. Results: The has a clear role renovating enhancing balance, prevents disorders, occurrence Adriamycin. Conclusion: contributes, as dose, preventing