Correlation and prediction of mass transport across membranes I: Influence of alkyl chain length on flux‐determining properties of barrier and diffusant

摘要: Abstract The effect of alkyl chain length on the physicochemical properties a series p -aminobenzoate esters, determinant rate at which they penetrate inert barriers, was investigated. Relationships are drawn for influence partition coefficient and solubility; these, in conjunction with diffusion layer membrane model, have been incorporated into general, theoretical expression maximum steady-state flux as function homolog size. This predicts parabolic dependency homologous is ascended certain reasonably normal conditions. model tested found valid an uninterrupted ester containing from one to seven carbons, utilizing dimethylpolysiloxane membranes. An analysis each parameter equation performed computer assistance. shows extent optimum absorption (barrier penetration) dependent controllable uncontrollable experimental factors. broad applications superimposed solubility constraints interpretation transport phenomena, including bioavailability, detailed.