Endosomal transport via ubiquitination

摘要: Cell survival, growth, differentiation and homeostasis rely on exquisite control of the abundance particular cell-surface membrane proteins. Cell-surface proteins must respond appropriately to environmental intracellular cues, often undergoing regulated internalization lysosomal degradation. These also can sustain damage be recognized removed. A unifying mechanism has emerged for trafficking damaged downregulated lysosome by their attachment ubiquitin (Ub), which serves as a sorting signal clathrin-mediated into late endosomes. Major questions remain how this system is governed, it adapted different proteins, whether Ub more than one-way ticket Here, we highlight recent insights challenges that remain.