Effects of dexamethasone, corticosterone, and ACTH on lordosis in ovariectomized and adrenalectomized-ovariectomized rats.

作者: Denys De Catanzaro , Boris B. Gorzalka

DOI: 10.1016/0091-3057(80)90356-1

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摘要: The involvement of the pituitary-adrenocortical axis in control lordosis reflex was investigated; In Experiment 1, estrogen-primed ovariectomized (ovx) and adrenalectomized-ovariectomized (adx-ovx) females were treated chronically with dexamethasone, a compound blocking ACTH release from pituitary. Dexamethasone inhibited lordosis, effectively an adrenalectomy-induced facilitation reflex. 2, corticosterone similarly administered chronically; this also adx-ovx females. 3, acute peripheral administration synthetic caused marked increase ovx results suggest that adrenally intact animal, may exert its effect through adrenal steroids. An elevation steroids whereas chronic decrease it.

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