Increase of serum fractalkine and fractalkine gene expression levels in sickle cell disease patients
作者： Selma Unal , Ozlem Ozdemir , Ahmet Ata Ozcimen , Yesim Oztas
DOI: 10.1007/S12185-014-1718-4
关键词:
摘要: In the present study, we examined role of fractalkine (Fkn), a member chemokine family, in pathogenesis sickle cell disease (SCD). Eighty-seven children with and 55 healthy were enrolled study. Complete blood counts, serum levels C-reactive protein, tumor necrosis factor-α, interferon-γ fractalkine, gene expression Fkn investigated. Serum values significantly higher SCD group compared to control (P < 0.05). The findings elevated both vaso-occlusive crisis stable forms suggest that this may be involved inflammation observed SCD. This study is first our knowledge describe relationship
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