Noxious Cold Ion Channel TRPA1 Is Activated by Pungent Compounds and Bradykinin

作者: Michael Bandell , Gina M Story , Sun Wook Hwang , Veena Viswanath , Samer R Eid

DOI: 10.1016/S0896-6273(04)00150-3

关键词:

摘要: … In this study, we have screened natural sensory compounds for TRPA1 activation and show … is expressed in trigeminal neurons that project to the tongue. Therefore, TRPA1 could …

参考文章(29)
Elaine Sullivan, Emily M. Tucker, Ian L. Dale, Measurement of [Ca2+] using the Fluorometric Imaging Plate Reader (FLIPR). Methods of Molecular Biology. ,vol. 114, pp. 125- 133 ,(1999) , 10.1385/1-59259-250-3:125
Louis S. Premkumar, Gerard P. Ahern, Induction of vanilloid receptor channel activity by protein kinase C Nature. ,vol. 408, pp. 985- 990 ,(2000) , 10.1038/35050121
Ardem Patapoutian, Andrea M. Peier, Gina M. Story, Veena Viswanath, ThermoTRP channels and beyond: mechanisms of temperature sensation Nature Reviews Neuroscience. ,vol. 4, pp. 529- 539 ,(2003) , 10.1038/NRN1141
Baruch Minke, The TRP Channel and Phospholipase C-Mediated Signaling Cellular and Molecular Neurobiology. ,vol. 21, pp. 629- 643 ,(2001) , 10.1023/A:1015191702536
David Julius, Allan I. Basbaum, Molecular mechanisms of nociception Nature. ,vol. 413, pp. 203- 210 ,(2001) , 10.1038/35093019
Réjean Couture, Madelaine Harrisson, Rose Mari Vianna, Frank Cloutier, Kinin receptors in pain and inflammation European Journal of Pharmacology. ,vol. 429, pp. 161- 176 ,(2001) , 10.1016/S0014-2999(01)01318-8
M. Tominaga, M. Wada, M. Masu, Potentiation of capsaicin receptor activity by metabotropic ATP receptors as a possible mechanism for ATP-evoked pain and hyperalgesia Proceedings of the National Academy of Sciences of the United States of America. ,vol. 98, pp. 6951- 6956 ,(2001) , 10.1073/PNAS.111025298
MARGARET CLIFF, HILDEGARDE HEYMANN, Descriptive Analysis of Oral Pungency Journal of Sensory Studies. ,vol. 7, pp. 279- 290 ,(1992) , 10.1111/J.1745-459X.1992.TB00195.X
Hiroyuki Watanabe, Joris Vriens, Jean Prenen, Guy Droogmans, Thomas Voets, Bernd Nilius, Anandamide and arachidonic acid use epoxyeicosatrienoic acids to activate TRPV4 channels Nature. ,vol. 424, pp. 434- 438 ,(2003) , 10.1038/NATURE01807