Dietary Chlorella vulgaris Ameliorates Altered Immunomodulatory Functions in Cyclophosphamide-Induced Immunosuppressive Mice

摘要: Based on the well-known toxicity of cyclophosphamide (CYP) immune system, this research investigated modulating effects long-term dietary Chlorella vulgaris (CV) supplementation immunosuppression induced by CYP in mice, order to provide a novel design mitigate side therapy. Control, CYP-treated, + CV (6%), (12%) and (24%) were used for 6 weeks, supplement diet recovered significantly reduced immunological function treated mice. As may have through inducible expression cytokines, we assayed expressions interleukin-2 (IL-2), interleukin-12 (IL-12), tumor necrosis factor-α (TNF-α) interferon-γ (IFN-γ). Our results suggested that lymphocytes proliferation phagocytic activities macrophages, stimulated production IL-2, IL-12, TNF-α IFN-γ impairment has been successfully adjusted supplementation. Treatment with algae also enhanced natural killer (NK) cells cytotoxicity, ameliorate histological changes spleen CYP-treated Therefore, as found study, supplemented whole beneficial CVP-induced immunosuppression, its immunomodulatory potential.