In vivo drug target discovery: identifying the best targets from the genome.
作者： D.Wade Walke , Chunsheng Han , Joseph Shaw , Elisabeth Wann , Brian Zambrowicz
DOI: 10.1016/S0958-1669(01)00271-3
关键词:
摘要: A vast number of genes unknown function threaten to clog drug discovery pipelines. To develop therapeutic products from novel genomic targets, it will be necessary correlate biology with gene sequence information. Industrialized mouse reverse genetics is being used determine in the context mammalian physiology and identify best targets for development.
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sci-hub.se 参考文章(22)
Airu S. Chen, Donald J. Marsh, Myrna E. Trumbauer, Easter G. Frazier, Xiao-Ming Guan, Hong Yu, Charles I. Rosenblum, Aurawan Vongs, Yue Feng, Linhai Cao, Joseph M. Metzger, Alison M. Strack, Ramon E. Camacho, Theodore N. Mellin, Christian N. Nunes, William Min, Jill Fisher, Shobhna Gopal-Truter, D. Euan MacIntyre, Howard Y. Chen, Lex H.T. Van der Ploeg, Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nature Genetics. ,vol. 26, pp. 97- 102 ,(2000) , 10.1038/79254
Brian P. Zambrowicz, Glenn A. Friedrich, Eric C. Buxton, Stan L. Lilleberg, Christophe Person, Arthur T. Sands, Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells Nature. ,vol. 392, pp. 608- 611 ,(1998) , 10.1038/33423
Rada Rouse, Tonga joins list of laboratory communities. Nature Medicine. ,vol. 7, pp. 8- 8 ,(2001) , 10.1038/83413
Mario R. Capecchi, Generating mice with targeted mutations. Nature Medicine. ,vol. 7, pp. 1086- 1090 ,(2001) , 10.1038/NM1001-1086
Airu S. Chen, Joseph M. Metzger, Myrna E. Trumbauer, Xiao-ming Guan, Hong Yu, Easter G. Frazier, Donald J. Marsh, Michael J. Forrest, Shobhna Gopal-Truter, Jill Fisher, Ramon E. Camacho, Alison M. Strack, Theodore N. Mellin, D. Euan MacIntyre, Howard Y. Chen, Lex H.T. Van der Ploeg, Role of the melanocortin-4 receptor in metabolic rate and food intake in mice. Transgenic Research. ,vol. 9, pp. 145- 154 ,(2000) , 10.1023/A:1008983615045
Lutfi Abu-Elheiga, Martin M Matzuk, Khaled AH Abo-Hashema, Salih J Wakil, Continuous Fatty Acid Oxidation and Reduced Fat Storage in Mice Lacking Acetyl-CoA Carboxylase 2 Science. ,vol. 291, pp. 2613- 2616 ,(2001) , 10.1126/SCIENCE.1056843
Dennis Huszar, Catherine A Lynch, Victoria Fairchild-Huntress, Judy H Dunmore, Qing Fang, Lucy R Berkemeier, Wei Gu, Robert A Kesterson, Bruce A Boston, Roger D Cone, Francoise J Smith, L.Arthur Campfield, Paul Burn, Frank Lee, Targeted disruption of the melanocortin-4 receptor results in obesity in mice Cell. ,vol. 88, pp. 131- 141 ,(1997) , 10.1016/S0092-8674(00)81865-6
Dennis Yamashita, Robert Dodds, Cathepsin K and the design of inhibitors of cathepsin K Current Pharmaceutical Design. ,vol. 6, pp. 1- 24 ,(2000) , 10.2174/1381612003401569
Jay A. Gingrich, René Hen, Dissecting the role of the serotonin system in neuropsychiatric disorders using knockout mice. Psychopharmacology. ,vol. 155, pp. 1- 10 ,(2001) , 10.1007/S002130000573
P. Saftig, E. Hunziker, O. Wehmeyer, S. Jones, A. Boyde, W. Rommerskirch, J. D. Moritz, P. Schu, K. von Figura, Impaired osteoclastic bone resorption leads to osteopetrosis in cathepsin-K-deficient mice Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 13453- 13458 ,(1998) , 10.1073/PNAS.95.23.13453