Section Review: Central & Peripheral Nervous Systems: Corticotropin releasing factor and Alzheimer's disease: recent developments with implications for more effective therapies
作者： Dominic P Behan , Stephen C Heinrichs , Errol B De Souza
DOI: 10.1517/13543784.5.10.1277
关键词:
摘要: Alzheimer's disease (AD) is a progressive degenerative of the nervous system characterised neuropathologically by presence senile plaques and neurofibrillary tangles in amygdala, hippocampus neocortex [1,2]. Dysfunction death basal cholinergic neurones projecting to forebrain targets are associated with marked decreases markers, including activity choline acetyl transferase [3]. Although cerebral cortical levels somatostatin receptors have been reported be reduced AD, no consistent changes other neuropeptide systems [4,5]. Here we review current understanding role corticotropin releasing factor (CRF) AD discuss possibilities exploiting this for molecular therapy treat AD.
sci-hub.st 参考文章(52)
E F Remmers, R L Wilder, T C Friedman, H Sano, L J Crofford, P Mathern, G P Chrousos, H R Epps, K Karalis, Corticotropin-releasing hormone in synovial fluids and tissues of patients with rheumatoid arthritis and osteoarthritis. Journal of Immunology. ,vol. 151, pp. 1587- 1596 ,(1993)
DT Chalmers, TW Lovenberg, EB De Souza, Localization of novel corticotropin-releasing factor receptor (CRF2) mRNA expression to specific subcortical nuclei in rat brain: comparison with CRF1 receptor mRNA expression The Journal of Neuroscience. ,vol. 15, pp. 6340- 6350 ,(1995) , 10.1523/JNEUROSCI.15-10-06340.1995
L J Crofford, H Sano, K Karalis, E L Webster, E A Goldmuntz, G P Chrousos, R L Wilder, Local secretion of corticotropin-releasing hormone in the joints of Lewis rats with inflammatory arthritis. Journal of Clinical Investigation. ,vol. 90, pp. 2555- 2564 ,(1992) , 10.1172/JCI116150
M.Maral Mouradian, John M. Farah, Erich Mohr, Giovanni Fabbrini, Thomas L. O'Donohue, Thomas N. Chase, Spinal fluid CRF reduction in Alzheimer's disease. Neuropeptides. ,vol. 8, pp. 393- 400 ,(1986) , 10.1016/0143-4179(86)90010-7
Tadeusz Pacholczyk, Randy D. Blakely, Susan G. Amara, Expression cloning of a cocaine- and antidepressant-sensitive human noradrenaline transporter. Nature. ,vol. 350, pp. 350- 354 ,(1991) , 10.1038/350350A0
Errol B. De Souza, George Battaglia, Increased corticotropin-releasing factor receptors in rat cerebral cortex following chronic atropine treatment. Brain Research. ,vol. 397, pp. 401- 404 ,(1986) , 10.1016/0006-8993(86)90647-5
D. P. Behan, E. A. Linton, P. J. Lowry, Isolation of the human plasma corticotrophin-releasing factor-binding protein Journal of Endocrinology. ,vol. 122, pp. 23- 31 ,(1989) , 10.1677/JOE.0.1220023
DENIS RICHARD, Involvement of Corticotropin‐Releasing Factor in the Control of Food Intake and Energy Expenditure Annals of the New York Academy of Sciences. ,vol. 697, pp. 155- 172 ,(1993) , 10.1111/J.1749-6632.1993.TB49930.X
ERROL B. DE SOUZA, PETER J. WHITEHOUSE, DONALD L. PRICE, WYLIE W. VALE, Abnormalities in corticotropin-releasing hormone (CRH) in Alzheimer's disease and other human disorders. Annals of the New York Academy of Sciences. ,vol. 512, pp. 237- 247 ,(1987) , 10.1111/J.1749-6632.1987.TB24964.X
Jacqueline N. Crawley, John A. Olschowka, Debra I. Diz, David M. Jacobowitz, Behavioral investigation of the coexistence of substance P, corticotropin releasing factor, and acetylcholinesterase in lateral dorsal tegmental neurons projecting to the medial frontal cortex of the rat Peptides. ,vol. 6, pp. 891- 901 ,(1985) , 10.1016/0196-9781(85)90320-1