Oral statins and increased bone-mineral density in postmenopausal women
作者： CJ Edwards , DJ Hart , TD Spector
DOI: 10.1016/S0140-6736(00)02408-9
关键词:
摘要: Experimental evidence suggests that the cholesterol-lowering drugs statins increase bone formation. We report a significant of bone-mineral density associated with taking in postmenopausal women.
elsevier.com
sci-hub.se 参考文章(4)
J. E. Fisher, M. J. Rogers, J. M. Halasy, S. P. Luckman, D. E. Hughes, P. J. Masarachia, G. Wesolowski, R. G. G. Russell, G. A. Rodan, A. A. Reszka, Alendronate mechanism of action: geranylgeraniol, an intermediate in the mevalonate pathway, prevents inhibition of osteoclast formation, bone resorption, and kinase activation in vitro Proceedings of the National Academy of Sciences of the United States of America. ,vol. 96, pp. 133- 138 ,(1999) , 10.1073/PNAS.96.1.133
M E Lloyd, D J Hart, D Nandra, T E McAlindon, M Wheeler, D V Doyle, T D Spector, Relation between insulin-like growth factor-I concentrations, osteoarthritis, bone density, and fractures in the general population: the Chingford study. Annals of the Rheumatic Diseases. ,vol. 55, pp. 870- 874 ,(1996) , 10.1136/ARD.55.12.870
G Mundy, R Garrett, S Harris, J Chan, D Chen, G Rossini, B Boyce, M Zhao, Gl Gutierrez, Stimulation of Bone Formation in Vitro and in Rodents by Statins Science. ,vol. 286, pp. 1946- 1949 ,(1999) , 10.1126/SCIENCE.286.5446.1946
A. W. Alberts, J. Chen, G. Kuron, V. Hunt, J. Huff, C. Hoffman, J. Rothrock, M. Lopez, H. Joshua, E. Harris, A. Patchett, R. Monaghan, S. Currie, E. Stapley, G. Albers-Schonberg, O. Hensens, J. Hirshfield, K. Hoogsteen, J. Liesch, J. Springer, Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 77, pp. 3957- 3961 ,(1980) , 10.1073/PNAS.77.7.3957