Importance of serum prolactin determination in metastatic breast cancer patients.

摘要: The aim was to correlate prolactin concentrations in the sera of patients with metastatic breast cancer time interval appearance metastases their location and size. prospective study included 46 female histologically confirmed diagnosis cancer. were recruited from Health Center outpatient clinic University Hospital day-care hospital Banja Luka Bosnia Herzegovina January August 1988. follow up lasted 5 years. Serum measured all before (baseline levels) after therapy at regular intervals during observation period. Their compared 40 healthy women 33 other types who served as control groups. Time development size determined those baseline serum higher than (610 vs 442 mU/L; p=0.04; Mann-Whitney test) locations cancers (662 481 mU/L respectively; p=0.02; Mann Whitney test). Metastases developed hyperprolactinemic whereas a third normoprolactinemic free metastases. average occurrence very high significantly shorter that low (54.3 6.1 months; p < 0.001; In there significant correlation between concentration treatment (r= -0.47; p=0.03) (r=0.64; p=0.001). Hyperprolactinemia could be an indicator disease progression poor prognosis (authors)