Geranylgeranyl pyrophosphate performs as an endogenous regulator of adipocyte function via suppressing the LXR pathway
作者： Yu-Sheng Yeh , Tsuyoshi Goto , Nobuyuki Takahashi , Kahori Egawa , Haruya Takahashi
DOI: 10.1016/J.BBRC.2016.08.119
关键词:
摘要: Isoprenoids such as geranylgeranyl pyrophosphate (GGPP) influence various biological processes. Here we show that GGPP inhibits adipocyte differentiation via the liver X receptors (LXRs) pathway. Intracellular levels and synthase (Ggps) mRNA expression increases during differentiation. Ggps also in white adipose tissue of obese mice. addition reduces adipogenic marker genes fatty acid binding protein, peroxisome proliferator-activated receptor γ, insulin-stimulated glucose uptake. Similarly, over-expressing In contrast, knockdown promotes Inhibition by was partially reduced LXR agonist T0901317. Furthermore, up-regulates target These results suggest may act an endogenous regulator maturation through a mechanism dependent on
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