The DNA Damage Response, DNA Repair, and AML

摘要: Acute myeloid leukemia (AML)—especially when the condition arises out of a pre-existing melodysplastic syndrome or follows prior therapy with alkylating agents ionizing radiation—is frequently associated complex bone marrow karyotypes, including multiple numeric chromosomal abnormalities, diminutive marker chromosomes uncertain derivation, and interstitial gains losses genetic material. In addition, variety inheritied syndromes DNA repair defects convey high risk myelodysplasia leukemia. Together, these pieces evidence suggest that fundamental defect in damage recognition response pathways is an important component leukemogenesis. Here, basic are reviewed data on known abnormalities acute myelodysplastic summarized. inherited predisposes to outlined, Fanconi anemia, Bloom syndrome, ataxia-telangiectasia ataxia-telangiectasia-like disorder, Nijmegen breakage Seckel others.