ROR nuclear receptors: structures, related diseases, and drug discovery
作者： Yan Zhang , Xiao-yu Luo , Dong-hai Wu , Yong Xu
DOI: 10.1038/APS.2014.120
关键词:
摘要: … retinoic acid receptor-related orphan receptors (RORs) have been implicated in several physiological and pathological processes. Therefore, RORs … , rheumatoid arthritis, and psoriasis. …
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J. Fraser Glickman, Xiang Wu, Robert Mercuri, Chantal Illy, Benjamin R. Bowen, Yang He, Matthew Sills, A comparison of ALPHAScreen, TR-FRET, and TRF as assay methods for FXR nuclear receptors. Journal of Biomolecular Screening. ,vol. 7, pp. 3- 10 ,(2002) , 10.1177/108705710200700102
Jie Shen, Jing Jiang, Guanglin Kuang, Chengfang Tan, Guixia Liu, Jin Huang, Yun Tang, Discovery and structure-activity analysis of selective estrogen receptor modulators via similarity-based virtual screening. European Journal of Medicinal Chemistry. ,vol. 54, pp. 188- 196 ,(2012) , 10.1016/J.EJMECH.2012.04.041
R. Evans, The steroid and thyroid hormone receptor superfamily Science. ,vol. 240, pp. 889- 895 ,(1988) , 10.1126/SCIENCE.3283939
Huang Huang, Ying Yu, Zhenting Gao, Yong Zhang, Chenjing Li, Xing Xu, Hui Jin, Wenzhong Yan, Ruoqun Ma, Jin Zhu, Xu Shen, Hualiang Jiang, Lili Chen, Jian Li, Discovery and optimization of 1,3,4-trisubstituted-pyrazolone derivatives as novel, potent, and nonsteroidal farnesoid X receptor (FXR) selective antagonists. Journal of Medicinal Chemistry. ,vol. 55, pp. 7037- 7053 ,(2012) , 10.1021/JM3002718
A. R. Chopra, J.-F. Louet, P. Saha, J. An, F. DeMayo, J. Xu, B. York, S. Karpen, M. Finegold, D. Moore, L. Chan, C. B. Newgard, B. W. O'Malley, Absence of the SRC-2 Coactivator Results in a Glycogenopathy Resembling Von Gierke's Disease Science. ,vol. 322, pp. 1395- 1399 ,(2008) , 10.1126/SCIENCE.1164847
Ivaylo I. Ivanov, Liang Zhou, Dan R. Littman, Transcriptional regulation of Th17 cell differentiation Seminars in Immunology. ,vol. 19, pp. 409- 417 ,(2007) , 10.1016/J.SMIM.2007.10.011
Xuexian O. Yang, Bhanu P. Pappu, Roza Nurieva, Askar Akimzhanov, Hong Soon Kang, Yeonseok Chung, Li Ma, Bhavin Shah, Athanasia D. Panopoulos, Kimberly S. Schluns, Stephanie S. Watowich, Qiang Tian, Anton M. Jetten, Chen Dong, T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ Immunity. ,vol. 28, pp. 29- 39 ,(2008) , 10.1016/J.IMMUNI.2007.11.016
Ting Yang, Qian Liu, Yaobang Cheng, Wei Cai, Yingli Ma, Liuqing Yang, Qianqian Wu, Lisa A. Orband-Miller, Ling Zhou, Zhijun Xiang, Melanie Huxdorf, Wei Zhang, Jing Zhang, Jia-Ning Xiang, Stewart Leung, Yang Qiu, Zhong Zhong, John D. Elliott, Xichen Lin, Yonghui Wang, Discovery of Tertiary Amine and Indole Derivatives as Potent RORγt Inverse Agonists. ACS Medicinal Chemistry Letters. ,vol. 5, pp. 65- 68 ,(2014) , 10.1021/ML4003875
Patrick Lau, Rebecca L. Fitzsimmons, Suryaprakash Raichur, Shu-Ching M. Wang, Adriane Lechtken, George E. O. Muscat, The Orphan Nuclear Receptor, RORα, Regulates Gene Expression That Controls Lipid Metabolism Journal of Biological Chemistry. ,vol. 283, pp. 18411- 18421 ,(2008) , 10.1074/JBC.M710526200
M. Steinmayr, E. Andre, F. Conquet, L. Rondi-Reig, N. Delhaye-Bouchaud, N. Auclair, H. Daniel, F. Crepel, J. Mariani, C. Sotelo, M. Becker-Andre, staggerer phenotype in retinoid-related orphan receptor -deficient mice Proceedings of the National Academy of Sciences. ,vol. 95, pp. 3960- 3965 ,(1998) , 10.1073/PNAS.95.7.3960