The mosaic genome of warm-blooded vertebrates.
作者： M Meunier-Rotival , F Rodier , G Bernardi , B Olofsson , J Filipski
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摘要: Most of the nuclear genome warm-blooded vertebrates is a mosaic very long (much greater than 200 kilobases) DNA segments, isochores; these isochores are fairly homogeneous in base composition and belong to small number major classes distinguished by differences guanine-cytosine (GC) content. The families molecules derived from such can be separated used study distribution any sequence which probed. This approach has revealed (i) that genes, integrated viral sequences, interspersed repeats highly nonuniform genome, (ii) ratio CpG GpC both coding noncoding as well codon usage, mainly depend on GC content harboring sequences. compositional compartmentalization discussed with respect its evolutionary origin, causes, effects chromosome structure function.
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