Longitudinal association between serum uric acid levels and multiterritorial atherosclerosis

摘要: Multiterritorial atherosclerosis has dramatically increased annual risk of adverse cardiovascular events than atherosclerotic disease with single-artery affected. Serum uric acid (SUA) is an important predictor stroke and atherosclerosis; however, which supported by few direct evidence based on cohort studies. A prospective study including 2644 North Chinese adults aged ≥40 years was performed in 2010-2012 to investigate the association between SUA multiterritorial vascular stenosis. Hyperuricaemia defined as levels >6 >7 mg/dL for males females, respectively. All participants underwent twice transcranial Doppler (TCD) bilateral carotid duplex ultrasound evaluate intracranial artery stenosis (ICAS) extracranial arterial (ECAS) peripheral (PAD) determined ankle-brachial index (ABI) January 2010 2012 regular health check-ups. The cumulative incidence significantly higher subjects hyperuricaemia those without (54.1% vs. 34.7%, P < 0.001). adjusted odds ratios (ORs) 95% confidence intervals (CIs) new on-set due a 1-mg/dL change level were 1.75 (1.32-2.31) 1.29 (1.21-1.38), Furthermore, gender-stratified analysis, ICAS statistically significant (OR: 2.02; CI: 1.18-3.46), but not females 0.85, 0.41-1.76, interaction: 0.026).