Chemotherapy for Advanced Non-small Cell Lung Cancer.

摘要: Non-small cell lung cancer has seen an unprecedented augmentation of therapeutic options over the last couple years. Improved understanding molecular drivers and role immune system in therapy have brought new drugs to armamentarium. Despite these advances, cytotoxic chemotherapy remains a substantial part for most patients locally advanced metastatic stage. Initially thought be chemotherapy-resistant entity, meta-analyses mid-1990s demonstrated modest efficacy platinum-based therapy. Further combination trials enhanced several regimen first second lines, including introduction antimetabolites, taxanes, anti-angiogenic agents. Maintenance been another novel, successful approach management disease. Herein, we summarize current concepts chemotherapy, its applicability different histologies, novel