摘要: Chronic lymphocytic leukemia developed in four of five siblings, whose father succumbed to the same disease. The pattern immune deficiency leukemic siblings resembled that found nonfamilial cases chronic leukemia, and was correlated with severity clinical involvement. In three peripheral blood cells shared delta-heavy kappa-light chains as only detectable surface immunoglobulin, suggesting on a cellular molecular level family members is identical. fourth youngest sibling had no lymphocytes immunoglobulin. An inherited defect class destined express appears underlie susceptibility this family.
sci-hub.st 参考文章(20)
R. M. Blaese, A. V. Muchmore, D. L. Nelson, The cytotoxic effector potential of some common non-lymphoid tumors and cultured cell lines with phytohemagglutinin and heterologous anti-erythrocyte antisera. Journal of Immunology. ,vol. 114, pp. 1001- 1003 ,(1975)
H. MELLSTEDT, D PETTERSSON, Lymphocyte subpopulations in chronic lymphocytic leukemia. Characterization by cell surface markers, cytotoxic activity, and mitogenic stimulation. Scandinavian Journal of Immunology. ,vol. 3, pp. 303- 310 ,(1974) , 10.1111/J.1365-3083.1974.TB01261.X
SM Fu, RJ Winchester, HG Kunkel, None, Similar Idiotypic Specificity for the Membrane IgD and IgM of Human B Lymphocytes Journal of Immunology. ,vol. 114, pp. 250- 254 ,(1975)
Leukemia in Close Relatives—Accident or Predisposition? Journal of the National Cancer Institute. ,vol. 42, pp. 517- 524 ,(1969) , 10.1093/JNCI/42.3.517
Howard M. Grey, Bernard Pirofsky, Ralph T. Kubo, IgD: A Major Immunoglobulin on the Surface of Lymphocytes from Patients with Chronic Lymphatic Leukemia Journal of Immunology. ,vol. 112, pp. 1952- 1954 ,(1974)
Abraham I. Potolsky, Clark W. Heath, C.E. Buckley, David T. Rowlands, Lymphoreticular malignancies and immunologic abnormalities in a sibship The American Journal of Medicine. ,vol. 50, pp. 42- 48 ,(1971) , 10.1016/0002-9343(71)90203-8
Tin Han, Studies of correlation of lymphocyte response to phytohemagglutinin with the clinical and immunologic status in chronic lymphocytic leukemia Cancer. ,vol. 31, pp. 280- 285 ,(1973) , 10.1002/1097-0142(197302)31:2<280::AID-CNCR2820310202>3.0.CO;2-O
JOSEPH F. FRAUMENI, Familial Chronic Lymphocytic Leukemia Annals of Internal Medicine. ,vol. 71, pp. 279- 284 ,(1969) , 10.7326/0003-4819-71-2-279
E. Vitetta, J. Uhr, Immunoglobulin-receptors revisited. Science. ,vol. 189, pp. 964- 969 ,(1975) , 10.1126/SCIENCE.1083069
D. S. ROWE, K. HUG, W. PAGE FAULK, J. N. MCCORMICK, H. GERBER, IgD on the surface of peripheral blood lymphocytes of the human newborn. Nature. ,vol. 242, pp. 155- 157 ,(1973) , 10.1038/NEWBIO242155A0