Remyelination through Engraftment

摘要: Publisher Summary This chapter examines and evaluates the therapeutic potential of achieving remyelination by transplantation myelin-forming cells. It also illustrates power glial-cell for examining aspects biology during development in pathological situations. The normal glial populations CNS PNS have an intrinsic replacement capacity. Two major issues must be addressed when undertaking interpreting studies. First, there is question identifying transplanted cells and, second, having a clear knowledge nature being transplanted. first issue has led to various experimental models use cellular markers track fate second different cell isolation expansion procedures that result enrichment particular phenotype. appreciated one may document results terms presence oligodendrocytes or Schwann Furthermore, discusses target diseases clinical situations where transplant-mediated would beneficial.