Crystal structure and catalytic activity of the PPM1K N94K mutant

作者: Meisam Rostaminasab Dolatabad , Lu-lu Guo , Peng Xiao , Zhongliang Zhu , Qing-tao He

DOI: 10.1111/JNC.14631

关键词:

摘要: … To understand the molecular mechanism underlying how N94K affect the catalytic activity of PPM1K, we expressed the truncated version of PPM1K-N94K (84-360) (Fig. S1). The …

参考文章(44)
A. K. Das, N. R. Helps, P. T. Cohen, D. Barford, Crystal structure of the protein serine/threonine phosphatase 2C at 2.0 A resolution. The EMBO Journal. ,vol. 15, pp. 6798- 6809 ,(1996) , 10.1002/J.1460-2075.1996.TB01071.X
Jiyong Su, Christine Schlicker, Karl Forchhammer, A Third Metal Is Required for Catalytic Activity of the Signal-transducing Protein Phosphatase M tPphA Journal of Biological Chemistry. ,vol. 286, pp. 13481- 13488 ,(2011) , 10.1074/JBC.M109.036467
Kristi E. Pullen, Ho-Leung Ng, Pei-Yi Sung, Matthew C. Good, Stephen M. Smith, Tom Alber, An Alternate Conformation and a Third Metal in PstP/Ppp, the M. tuberculosis PP2C-Family Ser/Thr Protein Phosphatase Structure. ,vol. 12, pp. 1947- 1954 ,(2004) , 10.1016/J.STR.2004.09.008
Jonathan Goldberg, Hsien-bin Huang, Young-guen Kwon, Paul Greengard, Angus C. Nairn, John Kuriyan, Three-dimensional structure of the catalytic subunit of protein serine/threonine phosphatase-1. Nature. ,vol. 376, pp. 745- 753 ,(1995) , 10.1038/376745A0
Z. Damuni, J. S. Humphreys, L. J. Reed, A potent, heat-stable protein inhibitor of [branched-chain alpha-keto acid dehydrogenase]-phosphatase from bovine kidney mitochondria. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 83, pp. 285- 289 ,(1986) , 10.1073/PNAS.83.2.285
Chang Pan, Jun-yi Tang, Yun-fei Xu, Peng Xiao, Hong-da Liu, Hao-an Wang, Wen-bo Wang, Fan-guo Meng, Xiao Yu, Jin-peng Sun, The catalytic role of the M2 metal ion in PP2Cα Scientific Reports. ,vol. 5, pp. 8560- 8560 ,(2015) , 10.1038/SREP08560
Giovanna Scapin, Molecular replacement then and now Acta Crystallographica Section D-biological Crystallography. ,vol. 69, pp. 2266- 2275 ,(2013) , 10.1107/S0907444913011426
Yu-Jie Du, Fan Yang, Ya Zhang, Nan Liang, Wei Yao, Ling-Li Zhang, Li-Chuan Gu, Cheng-Jiang Gao, Qi Pang, Yu-Xin Chen, Kun-Hong Xiao, Rong Ma, Xiao Yu, Jin-Peng Sun, Hong-Mei Wang, Yun-Fei Xu, Shang-Lei Ning, Du-Xiao Yang, Yi Li, The catalytic region and PEST domain of PTPN18 distinctly regulate the HER2 phosphorylation and ubiquitination barcodes. Cell Research. ,vol. 24, pp. 1067- 1090 ,(2014) , 10.1038/CR.2014.99
Chang Pan, Hong-Da Liu, Zheng Gong, Xiao Yu, Xu-Ben Hou, Di-Dong Xie, Xi-Bin Zhu, Hao-Wen Li, Jun-Yi Tang, Yun-Fei Xu, Jia-Qi Yu, Lian-Ying Zhang, Hao Fang, Kun-Hong Xiao, Yu-Guo Chen, Jiang-Yun Wang, Qi Pang, Wei Chen, Jin-Peng Sun, Cadmium is a potent inhibitor of PPM phosphatases and targets the M1 binding site Scientific Reports. ,vol. 3, pp. 2333- 2333 ,(2013) , 10.1038/SREP02333