Treatment of fibrosis using FXR ligands

作者: Stefano Fiorucci , Roberto Pellicciari , Mark Pruzanski

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摘要: The present invention relates to a method for inhibiting fibrosis that occurs in an organ where the farnesoid X receptor (FXR) is expressed. This involves step of administering high potency, activating ligand FXR effective amount patient who not suffering from cholestatic condition. also provides pharmaceutical compositions containing and kits dispensing compositions.

参考文章(101)
Jenny Heathcote, Update on primary biliary cirrhosis. Canadian Journal of Gastroenterology & Hepatology. ,vol. 14, pp. 43- 48 ,(2000) , 10.1155/2000/989486
Margrit Schwarz, Erik G. Lund, David W. Russell, Two 7α‐hydroxylase enzymes in bile acid biosynthesis Current Opinion in Lipidology. ,vol. 9, pp. 113- 118 ,(1998) , 10.1097/00041433-199804000-00006
Timothy D. Cushing, Steven Marc Rubenstein, Jonathan B. Houze, Lawrence R. Mcgee, John A. Flygare, Shi-Chang Miao, Jin-Long Chen, Patrick C. Kearney, La Brousse-Elwood Fabienne De, Juan C. Jaen, Ppar-gamma modulators ,(1999)
Julie Beth Stimmel, Timothy Mark Willson, Steven Gerard Blanchard, Steven A. Kliewer, Curt Dale Haffner, Jurgen M. Lehmann, Patrick Reed Maloney, Derek James Parks, Use of FXR ligands ,(2003)
Istvan Kaldor, Timothy Mark Willson, Robert Anthony Mook, Jeffrey Edmond Cobb, Grady Evan Boswell, Jon Loren Collins, Matthew Jude Sharp, David Norman Deaton, Brad Richard Henke, Marcus Brackeen, John Mark O'callaghan, Greg Alan Erickson, Substituted 4-hydroxy-phenylalcanoic acid derivatives with agonist activity to ppar-gamma ,(1997)
Isabelle Dussault, Barry M. Forman, Roshantha A. Chandraratna, Richard L. Beard, Composition and method for modulating bar/fxr receptor activity ,(2002)
Joseph Lester Giegel, Mary Mayer Brotherton, Solid phase system for ligand assay ,(1982)
Stacey A Jones, Derek J Parks, Steven A Kliewer, Cell-free ligand binding assays for nuclear receptors. Methods in Enzymology. ,vol. 364, pp. 53- 71 ,(2003) , 10.1016/S0076-6879(03)64004-8