Mycoplasma pneumoniae as an Under- Recognized Agent of Vasculitic Disorders

摘要: Mycoplasma pneumoniae, commonly known as a major causative agent of primary atypical pneumonia, also causes various kinds extrapulmonary manifestations involving almost all the organs human body. The author has classified due to M. pneumoniae infection into three categories: first is direct type in which locally induced cytokines play role, second an indirect immune modulation such autoimmunity plays and third vascular occlusion vasculitis and/or thrombosis with or without systemic hypercoagulable state role [Narita, 2009, 2010]. This classification system intended facilitate understanding pathogenesis infection. A diagram depicting possible ways can induce these types relation pathomechanism pneumonia shown Fig 1. Further concrete explanations each mechanism, based on accumulated in-vitro in-vivo data, are provided following sections. Of particular interest fact that cause many vasculitic/thrombotic disorders. may affect wall by inducing chemokines tumor necrosis factor-┙ interleukin-8, local vasculitic thrombotic state. Alternatively, generalized occur result turn consequence leading activation chemical mediators complements fibrin D-dimer. Although it already well few coagulation abnormality disorders disseminated intravascular stroke, remains under-recognized for other One reason this must be ability through operation absence apparent not yet widely known. In chapter, presents organ-specific associated