Detection of novel genetic markers of susceptibility to preeclampsia based on an analysis of the regulatory genes in the placental tissue
作者： V. N. Serebrova , E. A. Trifonova , T. V. Gabidulina , I. Yu. Bukharina , T. A. Agarkova
DOI: 10.1134/S0026893316050162
关键词:
摘要: Regulatory single nucleotide polymorphisms (rSNPs) are the least-studied group of SNP; however, they play an essential role in development human pathology by altering level candidate genes expression. In this work, we analyzed 29 rSNPs 17 new associated with preeclampsia (PE) according to analysis transcriptome placental tissue. Three ethnic groups have been studied (Yakut, Russian, and Buryat). We detected significant associations PE eight six differentially expressed genes, i.e., rs10423795 LHB gene; rs3771787 HK2 rs72959687 INHA rs12678229, rs2227262, rs3802252 NDRG1 rs34845949 SASH1 rs66707428 PPP1R12C gene. used a approach detecting genetic markers multifactorial diseases case based on combination genomic, transcriptomic, bioinformatic approaches. This proved its efficiency may be applied potential involved disease pathogenesis, which reduces missing heritability diseases.
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