Inhibition of 19S proteasome-associated deubiquitinases by metal-containing compounds.
作者： Ningning Liu , Hongbiao Huang , Q. Ping Dou , Jinbao Liu
关键词:
摘要: Copper and gold complexes have clinical activity in several diseases including cancer. Recently, we reported that the anti-cancer of copper (II) pyrithione CuPT (I) complex auranofin is associated with targeting 19S proteasome-associated deubiquitinases (DUBs), UCHL5 USP14. Here discuss metal DUB inhibitors treating cancer other diseases. (from Editor). Several some human tightly their ability to target inhibit In this article review small molecule DUBs DUBs. We then describe ubique nature auranofin, which inhibition finally suggest potential develop novel, specific metal-based for
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